Technology Hub for Spatial Omics
MULTI-SPACE
MULTI-SPACE is a pioneering interinstitutional technology platform that provides scientists across the Alliance institutions with cutting-edge, spatially-resolved multi-omics technologies. By leveraging the unique strengths, expertise, and resources of each institution, MULTI-SPACE envisions a collaborative environment where the latest advancements in omics and data analysis are accessible to drive new insights in health, disease, and cellular responses. MULTI-SPACE strives to establish, integrate, and expand the accessibility of spatially-resolved omics techniques across partner institutions, uniting technologies and analytical approaches that no single organization could fully achieve alone. By pooling advanced instrumentation and computational resources, currently housed primarily at EMBL Heidelberg and BioQuant at Heidelberg University, MULTI-SPACE enables scientists to conduct comprehensive, quantitative molecular analyses of tissues. This collaborative approach accelerates innovation in both foundational research and personalized disease therapies.
Advancing spatially resolved omics insights
The technology platform (1) provides scientists with access to state-of-the-art instrumentation, technologies, and computational analysis tools for spatially-resolved multi-omics research; (2) fosters a collaborative effort to overcome the technical challenges associated with integrating diverse omics methods with high-resolution, multimodal imaging; (3) addresses cellular heterogeneity in biomedical research, supporting both basic scientific questions and the development of personalized therapeutic approaches, and (4) supports the continuous development of emerging technologies, facilitating novel, holistic analyses of cellular functions, environmental influences, and drug responses.
Technologies
MULTI-SPACE provides assisted access to commercial as well as custom-made instrumentation for quantitative and molecular analysis methods that utilize spatially resolved multi-omics techniques with single-cell resolution, including data management and analysis support.
Lambda Vector workstation with 64 and 24 cores, for Image analysis
Image Analysis Consulting
MULTI-SPACE data server to download data generated at BioQuant hub. Data transfer across institutions: SDS@hd storage and DKFZ
Microscopy unit: 8-band excitation (DAPI – NIR), highly sensitive camera (~95% QE), Andor Sona CMOS detector, hardware AF, 20x-60x ir imaging
Slide scanner (Zeiss)
Autostainer (Parhelia)
Microscope (Keyence BZ-X800)
Oncotopix AI software (Visiopharm)
Antibody Conjugation Consultation
In development
Custom Cartana/PadFISH microscope
Robotic microscope
Spatial Transcriptomics
Spatial Proteomics
Spatial Metabolomics
How to get started
If you’re interested in utilizing our services, please reach out to us at multi-space[at]health-life-sciences.de. We’ll discuss the range of methodologies available for your project and help determine the best technology to meet your specific needs. Each methodology offers unique advantages, and we’ll work with you to select the most suitable approach for a successful project outcome.
For project consultation and image analysis support, don’t hesitate to contact us.